https://answers.microsoft.com/en-us/windows/forum/windows_vista-files/can-i-delete-the-file-cwindowswinsxsmanifestcache/3d83a43c-0af1-448f-8bda-8150ff201d2e


a. Click on start and type cmd in the search bar and right click on cmd.exe in the search pane and click Run as administrator.
n. Navigate to folder C:\Windows\Winsxs
c. Run this command:
   Net stop trustedinstaller
NOTE: Wait for this service to stop and ensure it stops successfully. If you are unable to stop the service, you must restart your machine. Do not attempt the next step if you are unable to stop the trustedinstaller service.
 
d. Then execute these commands:
   Takeown /f %windir%\winsxs\ManifestCache\*



e. You should now have available, some more free disk space.

Icacls %windir%\winsxs\ManifestCache\* /GRANT administrators:F
Del /q %windir%\winsxs\ManifestCache\*   

net start trustedinstaller